Omega 3 Fatty Acids Promising For Nerve Damage

Today's post from sciencedaily.com (see link below) reinforces the information provided in a post from 2 days ago on this blog and that is that fish oil, reinforced with Omega 3 fatty acids may well be of great benefit to damaged nerves. It has been found that one type of omega 3 fatty acid called resolvins, can restore nerve health in mice. Now we're pretty familiar with studies carried out on long-suffering rodents and can become blasé about yet more potential benefits that haven't been proved in humans. They generally mean that whatever the latest finding may be, it will be years before it reaches our doctor's prescription pad but in this case, taking fish oil supplements to compensate our lack of fish in our diets may not be such a bad idea anyway - if they can also improve our nerve problems in the meantime, until the science proves it beyond doubt, then it's pretty much a win-win situation.

Fish oil may help with diabetic neuropathy
Source:American Physiological Society Date:May 6, 2015 

(APS)Summary:

Approximately 50 percent of patients with diabetes suffer from nerve damage, or neuropathy. No cure exists, and the most effective treatment, keeping blood sugar in control, only slows neuropathy. A new study, however, introduces a new alternative, omega-3 fatty acids found in fish oil. The study shows that fish oil supplements can restore the condition of nerves damaged from diabetes in mice.

"Diabetic neuropathy is a very costly and debilitating complication of diabetes. It is the leading cause of foot ulcers and non-trauma-related amputations, and the impact of diabetic neuropathy on the patient and family are unmeasurable," said Mark Yorek of the VA Medical Center in Iowa City, the study's lead investigator. Fish oil is an attractive treatment approach because "supplements are considered very safe and could be easily translated into everyday care. Fish oil would be easy to take, like a vitamin, and should have few side effects when combined with other medications," explained Yorek.

Previous studies of obesity and diabetes have reported better blood sugar handling, liver function and reduced inflammation with omega-3 fatty acids treatment. The health benefits were attributed to protective molecules produced from omega-3 fatty acids, including one type called resolvins. The research group had previously observed that diets enriched with omega-3 fatty acids from fish oil improved diabetic neuropathy in rats with Type 1 and Type 2 diabetes, and in this new study they examined why.

Researchers used a mouse model of diabetes to study the effect of fish oil. Diabetic mice were fed a high-fat diet and treated with daily injections of resolvin or given a high-fat diet in which half the fat came from fish oil. The results were compared to healthy, non-diabetic mice.

The researchers found that untreated diabetic mice had diminished sense of touch in their paws that corresponded to fewer nerves in the paw's skin and slower transmission of signals along the nerves. The eyes of untreated diabetic mice also had fewer nerves. Though dietary fish oil and resolvin did not lower glucose levels closer to healthy range, they improved nerve health in terms of density and sensory signal transmission. The researchers also observed that resolvin stimulated nerve cells to grow.

"Even though a lot more work needs to be done, including clinical trials with human subjects, our animal studies suggest that fish oil can reverse some of the harmful effects of diabetes on the nerves. Our intent is to do more animal studies to demonstrate that fish oil treatment can reverse the harmful effects of diabetes on nerves even after a long period of poorly controlled diabetes. After completion of this work, we hope to begin studies with diabetic patients with neuropathy," Yorek said.

Story Source:

The above story is based on materials provided by American Physiological Society (APS). Note: Materials may be edited for content and length.

Journal Reference:
Hanna Shevalye, Matthew S Yorek, Lawrence J Coppey, Amey Holmes, Matthew M Harper, Randy H Kardon, Mark A. Yorek. Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. Journal of Neurophysiology, 2015; jn.00224.2015 DOI: 10.1152/jn.00224.2015

http://www.sciencedaily.com/releases/2015/05/150506182713.htm