3-D Digital Print-Outs To Restore Damaged Nerves

Today's post from the always-reliable, sciencedaily.com (see link below) looks at the potential use of 3-D printed, custom silicone guides implanted with biochemical cues to help nerve regeneration after injury. Now this isn't the replacing of damaged nerves caused by any number of factors that we know of as being neuropathy (maybe later) but it is a major breakthrough with enormous potential. It's also not printing out digital 'plastic 'nerves' that could function as real ones - it's the placing of the right 'stimuli' between damaged nerve ends to encourage them to rejoin naturally. Of course, at the moment, experiments have only taken place on rats and who knows how long it will be before damaged nerves are regenerated in this way in humans but everybody living with neuropathy will be excited at the prospect of having a sort of, 'nerve transplant' in the same way that other organs of the body are currently transplanted. Science fiction? Not any more!

3-D printed guide helps regrow complex nerves after injury 
Date:September 18, 2015 Source:University of Minnesota

Summary:

Scientists have developed a first-of-its-kind, 3-D printed guide that helps regrow both the sensory and motor functions of complex nerves after injury. The groundbreaking research has the potential to help more than 200,000 people annually who experience nerve injuries or disease.


This is a 3-D printed nerve regeneration pathway implanted in a rat helped to improve walking in 10 to 12 weeks after implantation.
Credit: University of Minnesota College of Science and Engineering

A national team of researchers has developed a first-of-its-kind, 3D-printed guide that helps regrow both the sensory and motor functions of complex nerves after injury. The groundbreaking research has the potential to help more than 200,000 people annually who experience nerve injuries or disease.

Collaborators on the project are from the University of Minnesota, Virginia Tech, University of Maryland, Princeton University, and Johns Hopkins University.

Nerve regeneration is a complex process. Because of this complexity, regrowth of nerves after injury or disease is very rare, according to the Mayo Clinic. Nerve damage is often permanent. Advanced 3D printing methods may now be the solution.

In a new study, published today in the journal Advanced Functional Materials, researchers used a combination of 3D imaging and 3D printing techniques to create a custom silicone guide implanted with biochemical cues to help nerve regeneration. The guide's effectiveness was tested in the lab using rats.

To achieve their results, researchers used a 3D scanner to reverse engineer the structure of a rat's sciatic nerve. They then used a specialized, custom-built 3D printer to print a guide for regeneration. Incorporated into the guide were 3D-printed chemical cues to promote both motor and sensory nerve regeneration. The guide was then implanted into the rat by surgically grafting it to the cut ends of the nerve. Within about 10 to 12 weeks, the rat's ability to walk again was improved.

"This represents an important proof of concept of the 3D printing of custom nerve guides for the regeneration of complex nerve injuries," said University of Minnesota mechanical engineering professor Michael McAlpine, the study's lead researcher. "Someday we hope that we could have a 3D scanner and printer right at the hospital to create custom nerve guides right on site to restore nerve function."

Scanning and printing takes about an hour, but the body needs several weeks to regrow the nerves. McAlpine said previous studies have shown regrowth of linear nerves, but this is the first time a study has shown the creation of a custom guide for regrowth of a complex nerve like the Y-shaped sciatic nerve that has both sensory and motor branches.

"The exciting next step would be to implant these guides in humans rather than rats," McAlpine said. In cases where a nerve is unavailable for scanning, McAlpine said there could someday be a "library" of scanned nerves from other people or cadavers that hospitals could use to create closely matched 3D-printed guides for patients.

In addition to McAlpine, major contributors to the research team include Blake N. Johnson, Virginia Tech; Xiaofeng Jia, University of Maryland and Johns Hopkins University; and Karen Z. Lancaster, Esteban Engel, and Lynn W. Enquist, Princeton University.

This research was funded by grants from the National Institutes of Health, the Defense Advanced Research Projects Agency, the Maryland Stem Cell Research Fund, and the Grand Challenges Program at Princeton University.

To read more about the study entitled "3D Printed Anatomical Nerve Regeneration Pathways," visit the Advanced Functional Materials website.

Story Source:

The above post is reprinted from materials provided by University of Minnesota. Note: Materials may be edited for content and length.

Journal Reference: 
 
Blake N. Johnson, Karen Z. Lancaster, Gehua Zhen, Junyun He, Maneesh K. Gupta, Yong Lin Kong, Esteban A. Engel, Kellin D. Krick, Alex Ju, Fanben Meng, Lynn W. Enquist, Xiaofeng Jia, Michael C. McAlpine. 3D Printed Anatomical Nerve Regeneration Pathways. Advanced Functional Materials, 2015; DOI: 10.1002/adfm.201501760

http://www.sciencedaily.com/releases/2015/09/150918105030.htm