Today's short post from news-medical.net (see link below) is the first of two posts (see tomorrow) about Ketamine as an effective analgesic for chronic pain. This article doesn't mention neuropathic pain at all but tomorrow's post goes into great detail concerning prescribing Ketamine for chronic nerve pain. Today's post provides back up information about ketamine being reintroduced into the list of analgesics that may be considered alternatives for opioids. Ketamine has had a bad rap over the years, mainly due to recreational drug use and abuse but has been prescribed by doctors more or less, 'off-label' for both chronic after surgery pain and pain caused by injury. Many neuropathy patients have also benefited from ketamine prescriptions, just as they have from methadone, that has an equally bad press but very few doctors will issue ketamine without a great deal of knowledge and experience. Today's article and that from tomorrow, explain just why ketamine is a viable alternative to opioids and standard chronic pain relief drugs. Well worth a read but in combination with tomorrow's article too.
Reviewed by Alina Shrourou, BSc Oct 15 2018
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Intravenous, low-dose ketamine (LDK) is as effective as intravenous morphine in the control of acute pain in adults in the emergency department (ED). That is the finding of a study to be published in the October 2018 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM). The results indicate that ketamine can be considered as an alternative to opioids for ED short-term pain control.
The lead author of the study is Nicholas Karlow, MPHS, a medical student at the Washington University School of Medicine in St. Louis, Missouri. The findings of the study are discussed in the featured
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The systematic review and meta-analysis by Karlow, et al. maintains that there is a role for opioids in the treatment of pain in the ED, but suggest that as physicians continue to face pressure to reduce opioid use, it is important to establish that alternatives such as ketamine are comparable in providing patients with appropriate analgesia in a similar time frame.
The study further suggests that for patients with opioid use disorders or substance use disorders that require a potent analgesic in the emergency department, ketamine may be a favorable option compared to an opioid.
Moving forward, the authors suggest that observational studies assessing adverse events should use similar outcome measures and time frames, and that researchers should explore patient and physician satisfaction with ketamine analgesia and side effects compared to other opioid alternatives for acute pain.
"Karlow and colleagues provide persuasive evidence that emergency physicians can reasonably expect sub-dissociative ketamine to be as effective as morphine for patients with acute abdominal or musculoskeletal pain. Minor ketamine adverse effects will likely prevent this therapy from becoming routinely first line, but low dose ketamine represents a good alternative choice for selected patients," commented Steven M. Green, MD, professor of emergency medicine and residency director at Loma Linda University, California.
Dr. Green's principal research interest has been on procedural sedation and analgesia, with numerous studies of ketamine dating back to 1990 and more recent works relating to sedation's optimal practice, politics, and future. He is a deputy editor at Annals of Emergency Medicine journal.
Source:
http://saem.org/
https://www.news-medical.net/news/20181015/Ketamine-can-be-considered-as-alternative-to-opioids-for-short-term-pain-control-in-ED.aspx
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